CV

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Education

2011 - 2016
Ph.D. in Structural Biology, Weizmann Institute of Science.

2008 - 2011
M.Sc. in Structural Biology, Weizmann Institute of Science.

2005 - 2008
B.Sc. in Chemistry, Bar-Ilan University, graduated magna cum laude.

Research experience

Postdoc, Stanford University
Laboratory of Joseph Puglisi and Elisabetta Viani Puglisi.
Research focus: Architecture of HIV viral RNA.

Ph.D., Weizmann Institute of Science
Adviser: Ada Yonath.
Thesis: The Origin of the Ribosome and its Paralyzation by Antibiotics.

M.Sc., Weizmann Institute of Science
Adviser: Ada Yonath.
Thesis: Towards the Determination of the Structure of Mycobacterium smegmatis Ribosome.

Rotations at Weizmann Institute of Science
1) Ribosome structure and function, laboratory of Ada Yonath.
2) Organized lipid domains, laboratory of Lia Addadi.
3) Nano and bio composite materials, laboratory of Daniel Wagner.

Undergraduate research at Bar Ilan University
Conducting polymers, laboratory of Joseph Frey.

Publications

Advances in understanding the initiation of HIV-1 reverse transcription
Krupkin M*, Jackson LN*, Ha B*, Puglisi EV.
Current Opinion in Structural Biology, Volume 65, December 2020, Pages 175-183.
link.

Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus
Matzov D*, Eyal Z*, Benhamou RI, Shalev-Benami M, Halfon Y, Krupkin M, Zimmerman E, Rozenberg H, Bashan A, Fridman M, Yonath A.
Nucleic Acids Res. 2017 Sep 29;45(17):10284-10292.
link.

The ribosomal protein uL22 modulates the shape of the protein exit tunnel
Wekselman I, Zimmerman E, Davidovich C, Belousoff M, Matzov D, Krupkin M, Rozenberg H, Bashan A, Friedlander G, Kjeldgaard J, Ingmer H, Lindahl L, Zengel JM, Yonath A.
Structure. 2017 Aug 1;25(8):1233-1241.e3. Epub 2017 Jul 6.
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Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding
Krupkin M*, Wekselman I*, Matzov D, Eyal Z, Diskin Posner Y, Rozenberg H, Zimmerman E, Bashan A, Yonath A.
Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6796-E6805.
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A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism
Eyal Z*, Matzov D*, Krupkin M, Paukner S, Riedl R, Rozenberg H, Zimmerman E, Bashan A, and Yonath A.
Sci Rep. 2016 Dec 13;6:39004.
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Ribosomal antibiotics: Contemporary challenges
Auerbach-Nevo T, Baram D, Bashan A, Belousoff M, Breiner E, Davidovich C, Cimicata G, Eyal Z, Halfon Y, Krupkin M, … Yonath A.
Antibiotics (Basel). 2016 Jun 29;5(3). pii: E24.
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Structural insights into species-specific features of the ribosome from the pathogen staphylococcus aureus
Eyal Z*, Matzov D*, Krupkin M, Wekselman I, Paukner S, Zimmerman E, Rozenberg H, Bashan A, Yonath A.
Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):E5805-14.
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A recombinant collagen–mRNA platform for controllable protein synthesis
Sun L, Xiong Y, Bashan A, Zimmerman E, Shulman Daube S, Peleg Y, Albeck S, Unger T, Yonath H, Krupkin M, Matzov D, Yonath A.
Chembiochem. 2015 Jul 6;16(10):1415-9.
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Chapter 6: Glimpse into the origin of life: What was first, the genetic code or its products, the proteins?
Krupkin M, Bashan A, Yonath A.
“Why does Evolution Matter? The Importance of Understanding Evolution”, G. Trueba, ed. (Cambridge Scholars Publishing),(2014), p. 87-100.
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Protoribosome by quantum kernel energy method
Huang L, Krupkin M, Bashan A, Yonath A, Massa L.
Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14900-5.
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A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome
Krupkin M, Matzov D, Tang H, Metz M, Kalaora R, Belousoff MJ, Zimmerman E, Bashan A, Yonath A.
Philos Trans R Soc Lond B Biol Sci. 2011 Oct 27;366(1580):2972-8.
link.

The ribosome as drug target: lessons from 3D structures
Bashan A, Zimmerman E, Belousoff MJ, Rozenberg H, Davidovich C, Wekselman I, Shapira T, Krupkin M, Yonath A.
Isr Chem Soc. 2010, 25, 10-18.

The proto-ribosome : An ancient nano-machine for peptide bond formation
Davidovich C, Belousoff M, Wekselman I, Shapira T, Krupkin M, Zimmerman E, Bashan A, Yonath A.
Isr J Chem. 2010 Jun 18;50(1):29-35.

* Equal contribution.

Conferences and Presentations

2019

2016

2015

2014

2013

2012

2011

2010

Awards and Fellowships

Other Activities

2020

2019

2018

2017- 2019

2015

2013

2010

2009 - 2017